Epithalon’s short linear 4-residue amino acid sequence delivers unique blood-brain barrier penetrance and selective telomerase modulating activity unavailable to larger peptide molecules:
- Minimal tetrapeptide sequence (Ala-Glu-Asp-Gly) enables efficient trans-endothelial transport across the blood-brain barrier to modulate pineal gland and hypothalamic neuroendocrine signaling.
- Core molecular function: upregulation of human telomerase reverse transcriptase (hTERT) gene expression, stimulating telomere length maintenance in replicative senescent cell culture models, the central experimental focus of aging biology research.
- C-terminal amidation enhances serum proteolytic stability, extending measurable systemic biological activity in rodent lifespan studies.
- Dual neuroendocrine function: modulates melatonin circadian secretion from pineal tissue alongside telomere regulatory pathways, supporting combinatorial aging + circadian rhythm laboratory research.
| Property | Value |
|---|---|
| Full Name | Epithalon, Epitalon, Pineal Tetrapeptide Bioregulator |
| CAS Registry Number | 307297-39-8 |
| Molecular formula | C14H22N4O9 |
| Molecular weight | 390.34 g/mol |
| Peptide length | 4 amino acid tetrapeptide |
| Compound class | Synthetic pineal-derived longevity bioregulatory peptide |
| Primary molecular targets | hTERT telomerase gene expression, pineal melatonin synthesis, senescence-associated secretory phenotype (SASP) suppression |
| Physical form | White fine lyophilised powder |
| Solubility | Fully soluble in sterile bacteriostatic water, neutral PBS pH7.2 |
| Light sensitivity | Store sealed away from UV light to prevent photodegradation |
| Purity standard | ≥99% HPLC confirmed per batch COA |
| Standard ET/Epi-series stock sizes | ET/Epi10 (10mg), ET/Epi50 (50mg) |
Epithalon’s lifespan and senescence-regulating activity originates from decades of Russian geriatric preclinical pineal gland bioregulator research, validated across hundreds of peer-reviewed mammalian lifespan, cell culture senescence and neuroendocrine circadian rhythm publications. Core experimental models include replicative fibroblast senescence culture, rodent chronic aging lifespan tracking and age-related endocrine dysfunction assays.
The foundational body of Epithalon research was established by the Khavinson laboratory group, conducting long-term rodent lifespan cohort trials documenting consistent dose-dependent extension of median survival time, reduced age-related inflammatory SASP cytokine expression and stabilized telomere length in somatic tissue cells. These published datasets form the standardized reference protocol for modern telomerase and anti-senescence peptide laboratory research.
Epithalon is frequently co-tested with mitochondrial protective peptides (SS-31, MOTS-C) and copper anti-matrix peptides (GHK-CU) for multi-pathway longevity formulation research, combining telomere maintenance, oxidative stress defense and dermal matrix repair mechanisms. Zypep Peptides supplies standalone ET/Epi10 vials as well as multi-peptide anti-aging compound blends for combinatorial aging experimental design.
Zypep Peptides manufactures factory-direct bulk Epithalon lyophilized powder for university gerontology labs, senolytics biotech CROs and global peptide wholesale distributors. Request bulk volume pricing, full batch test COA and refrigerated international shipping quotations via the website floating chat dialog on zypep.com. All ET/Epi-series products marked FOR LABORATORY AGING RESEARCH USE ONLY, not intended for human therapeutic administration.
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