PT-141’s closed-ring cyclic seven-residue peptide backbone delivers high blood-brain barrier penetrance and selective central MC3/MC4 receptor agonism, distinguishing it from peripherally active melanocortin peptides like Melanotan 2 (MT-2):
- Cyclic heptapeptide ring structure confers enhanced proteolytic stability in systemic circulation, resisting serum protease degradation compared to linear melanocortin analogs.
- Selective binding to central hypothalamic MC3R and MC4R receptors with minimal peripheral MC1R skin pigmentation cross-activation, isolating reproductive limbic signaling pathways from cutaneous melanocyte stimulation for targeted neuroendocrine research.
- C-terminal amidation optimizes CNS tissue distribution following systemic administration, supporting ex-vivo hypothalamic explant culture and in-vivo rodent sexual behavior cohort studies.
- Distinct mechanistic separation from peripheral melanocortin peptides enables comparative central versus peripheral melanocortin pathway laboratory research.
| Property | Value |
|---|---|
| Full Name | PT-141, Bremelanotide Cyclic Melanocortin Heptapeptide |
| CAS Registry Number | 189691-06-3 |
| Molecular formula | C50H69N15O10 |
| Molecular weight | 1025.2 g/mol |
| Peptide length | 7 amino acid cyclic heptapeptide |
| Compound class | Synthetic central melanocortin MC3/MC4 receptor agonist neuroendocrine peptide |
| Primary molecular targets | Hypothalamic limbic MC3R, MC4R melanocortin receptors |
| Secondary minimal activity | Weak peripheral MC1R binding (no significant pigmentation at research doses) |
| Physical form | White crystalline lyophilised powder |
| Solubility | Sterile bacteriostatic water, neutral PBS pH7.0–7.5 |
| Purity standard | ≥99% HPLC cyclic peptide content per batch COA |
| Standard P-series stock size | P41 (10mg) |
PT-141’s central melanocortin-mediated reproductive signaling activity is validated across dozens of peer-reviewed neuroendocrinology, sexual behavior and hypothalamic explant laboratory publications spanning 20 years of melanocortin peptide research. Core experimental models include rodent sexual behavior observation cohorts, primary hypothalamic neuron culture MC receptor binding assays and luteinizing hormone (LH) reproductive hormone secretion tracking.
Original PT-141 preclinical and Phase 2 clinical research characterized the peptide’s unique CNS-selective MC agonism, demonstrating dose-dependent modulation of limbic sexual desire signaling without the peripheral tanning side effects observed with non-selective MT-2 melanocortin peptides. These published datasets form the standardized reference protocol for central reproductive melanocortin pathway comparative laboratory research.
PT-141 is frequently tested alongside Melanotan 1 and Melanotan 2 for central versus peripheral melanocortin receptor pathway contrast research, separating limbic reproductive signaling from cutaneous melanocyte pigmentation mechanisms. Zypep Peptides supplies standalone P41 PT-141 vials alongside MT-series melanotan peptides for multi-target melanocortin experimental design.
Zypep Peptides manufactures factory-direct bulk PT-141 lyophilized powder for university reproductive neuroendocrinology labs, behavioral preclinical CROs and global peptide wholesale distributors. Request bulk volume pricing, full cyclic peptide batch test COA and refrigerated international shipping terms via the website floating chat dialog on zypep.com. All P-series products marked FOR LABORATORY NEUROENDOCRINE RESEARCH USE ONLY, not intended for human therapeutic administration.
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